Yesterday’s doctors appointment went well. The genetic test results finally came in! So that was pretty exciting. They did find two mutations for which there are treatments, p53 and AKT1. The results from the genetic analysis were sent to a committee of oncologists at the Cancer Institute of NJ who made recommendations on treatments, both currently FDA approved and experimental. The approved treatments they recommended were Afinitor and Carboplatin, both of which were on my list of possible future drugs. Afinitor is known to cause mouth sores in more than 60% of people who take it and the main side effect for Carboplatin is low blood counts. The committee also recommended about 4 trials that are ongoing in the NJ area that might be good for me. The trials are all phase I, which means the treatments haven’t been proven to work, but they do target the specific mutations that I have which is a plus. I need to thoroughly read the report to get more details. One disappointment was that they were able to use the sample from my original mastectomy in 2009, but not EITHER of my liver biopsies (2012 &2013). The liver biopsies did not contain enough cancerous tissue to do this kind of highly specialized analysis. Dr H from CINJ told me that the mutations from the 2009 sample would still be present in the cancer cells growing in my body now, but it is likely that there are additional mutations (that have occurred since 2009). There is the option of doing another biopsy in the future, but Dr. T says we will need to consider the risks vs benefits.
For the moment I’m going to continue with Gemzar. I’ll be getting a PET scan next week to see how I’m doing. I also had a tumor marker drawn which should be available later this week. My counts were good yesterday, so I had my usual chemo as well as my Xgeva shot. I was pretty tired last night and went to bed early, but had to take a pain pill first because of body aches. My blood pressure has been consistently high over the last few months, so Dr. T gave me a water pill (HCTZ).
We’re still dealing with the snowpocalypse here in NJ….